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The product, which received FDA approval in March 2023, was approved based on data from the randomized, double-blind, placebo-controlled phase 3 LAVENDER study (ClinicalTrials. The dosage is determined by patient weight and can be administered orally or via gastrostomy tube. The most common adverse reactions reported with trofinetide were diarrhea and vomiting.

Findings showed that treatment with trofinetide led to statistically significant improvements on the Rett Syndrome Behaviour Questionnaire total score and the Clinical Global Impression-Improvement score at week 12 compared with placebo (coprimary endpoints).

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• clozapine
• droperidol
• halofantrine
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• pimozide

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• charcoal
• fluvoxamine
• levodopa and other medicines for Parkinson's disease
• medicines for diabetes
• medicines for high blood pressure
• medicines for mental depression, anxiety, other mood disorders, or sleeping problems
• omeprazole
• rifampin
• ritonavir
• tobacco from cigarettes

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